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Although there were already substantial levels of IL-21 at 42 hr in cells activated with IL-6, these levels steeply rose in the next 6 hr.
Previous statistical analyses of the numbers and distributions of these patterns have concluded that a substantial majority of these represent ancestral positions, indicating that there were already substantial intron numbers by the time of divergence.
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Such privileges are already substantial.
Those premiums are already substantial; for obstetricians and neurosurgeons, they can run to more than $100,000 annually.
"In going east to west, we're entering a new market for which there is already substantial competition.
There is already substantial pressure on film actors, especially young female ones, to take their clothes off for the camera.
The online market for drugs is already substantial, with probably more than a million Americans regularly participating.
There was already substantial academic and commercial work being done on synthesizers in places like Stanford University's computer department, the BBC Radiophonics Workshop, and the West German Broadcasting studio, in Cologne.
If that figure is then multiplied by the number of close relatives and friends, the population profoundly affected by what happened is already substantial.
Farther east there was already substantial regular use of the Lena-Kolyma section of the Northeast Passage by the mid-17th century.
But perhaps there's a way to keep on using the work that the band has amassed, at festivals or in the future at Carnegie Hall, and promoting the further growth of something that's already substantial.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com