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Graphical summaries of the correlations coefficients for strands four to nine are shown in Fig. 2 and Supplementary fig. 3. Normal modes and trajectories of mode displacements were additionally calculated from the same structure used in the elastic normal mode calculations using GROMACS with the CHARMM27 force field combined with the OBC (Onufriev, Bashford, Case) implicit solvent model51.

Variance components of level II variables were additionally calculated[ 10].

Bootstrap values were additionally calculated to infer branch support with 1000 replicates.

Z-scores were additionally calculated where appropriate using published equations [ 15- 17, 21].

The ratios of MMP-1/TIMP-1, MMP-3/TIMP-1 and MMP-9/TIMP-1 were additionally calculated.

As a prognosis indicator, CR, relapse, and death rates were used and both OS and event-free survival (EFS) were additionally calculated.

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The resistance (Ri) for these SDs was additionally calculated from Ohm's law as function of voltage for each diode.

For patients with liver cirrhosis, model of end-stage liver disease score (MELD) [25], Child Turcotte Pugh (CTP) score [26] and CLIF-SOFA score [3] were calculated on admission, and CLIF-SOFA was additionally calculated 24 and 48 h after ROSC.

Because the estimated coefficients of the Tobit-Model refer to the latent variable, marginal effects are additionally calculated, which represent the effects of the explanatory variables on the expected value of the dependent variable evaluated at the mean values of the explanatory variables.

The ratio of humulene to caryophyllene was additionally calculated.

For rs7498665 an asymptotic, 2-tailed p-value for the transmission disequilibrium test (TDT) was additionally calculated with PLINK.

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