The protest will not focus solely on increasing calls for Arsène Wenger to be removed.
Wenger decided to remove Francis Coquelin at half-time because the player was suffering a knee injury.
But, in recent years, far removed from Arsenal's glory days, Wenger's teams have come to seem twinkly and fussy, lacking the cunning and toughness necessary in moments of crisis.
Wenger added that the surprise results - which also removed Tottenham and third-placed Southampton from Monday's fifth-round draw - sparked Arsenal's impressive start at the Amex Stadium.
Arsène Wenger incurred boos by removing Alex Oxlade-Chamberlain for Andrei Arshavin at 1-1 but was indignant about the reaction to his decision.
And the simmering frustration burst to the surface when Wenger's decision to remove Lukas Podolski rather than game but raw youngster Yaya Sanogo for Olivier Giroud, with 21 minutes left and Wigan leading, was greeted with resounding jeers from Arsenal's fans.
They also remove any excuse Wenger might have for failing.
It is a reality, though, that if you can subdue this graceful operator then you remove one of Wenger's most potent weapons.
Wenger confirmed the procedure, which will remove a pin inserted during previous surgery, means Wilshere will return for Arsenal's pre-season campaign, which includes a tour of Asia.
A home win against local rivals Spurs will remove some of the pressure on Arsene Wenger.
