This is because that TFs binding to TFBSs in promoters is the most crucial and well understood step in gene regulation.
To date, transcription factor binding sites (TFBSs) have been widely used to measure the RS of two genes because transcription factors (TFs) binding to TFBSs in promoters is the most crucial and well understood step in gene regulation.
The ability to produce consistent data and well-understood, correctly applied definitions are critical steps in making sure that assessments are done fairly and evenly.
Particular types of backbone analogs also seem to be excluded during these translational steps [15], although exactly how they are rejected is not well-understood.
would fall into well-understood niches.
The carotenoid biosynthetic pathway is conserved in plants and has been best characterized in the model dicot Arabidopsis thaliana (Dellapenna and Pogson 2006; Kim et al. 2009; Cuttriss et al. 2011) in which the molecular basis of these hydroxylation steps is well understood.
Thus, overall PT kinetics at different temperature range is well understood by invoking in three step mechanism: I) early stage anatase-to-rutile transformation is dominated by interface-nucleation, II) then intermediate stage reversible rutile-to-anatase PT and, III) at later stages, anatase-to-rutile PT is controlled by dissolution precipitation mechanism.
Whereas factors involved in these steps are relatively well understood now, the mechanisms behind the origin specification, the choice of origins to be fired and determination of their timing are still under active investigation.
However, the actual gain in prediction efficiency using short time-step data is not well understood or quantified.
Through a series of steps that are still not well understood, these phagocytes activate the NLRP3 inflammasome, resulting in processing and secretion of IL-1β.
Although the role of LYST is less well understood, it may regulate a late granule maturation step.
