In order to shed light upon the potential of dietary PUFAs to modulate infection in invertebrates we used the freshwater crustacean Daphnia magna, which is well understood regarding its nutritional ecology.
Nevertheless all current compound scaffolds characterized by cocrystal structure analysis are highly specific for Mdm2 and show no or very little Mdm4 binding which is surprising and not well understood regarding the great similarity between the two proteins.
Although the basic principles of this process are well understood, information regarding the three-dimensional distribution of chloride ions within the object and its relationship to patterns of cracking and the development of corrosion behaviour is not currently available.
New insights were gained regarding the activities of some of the less well-understood sirtuins.
Secondary metabolism is an example of a complex network of biochemical pathways, which, although well mapped from a biochemical point of view, is not well understood with regards to its physiological roles and genetic and biochemical regulation.
While the water rock interactions that govern the dissolved constituents of produced waters are not well understood [5], information regarding the metal contents and mineralogy of the Marcellus Shale is necessary for assessing the potential for metal mobilization in situ or upon disposal of waste cuttings.
The prolonged pathophysiology in the remaining musculature following VML is not well understood, raising questions regarding appropriate physical rehabilitation regimen.
Nevertheless, the effects of postoperative rehabilitation on the uninvolved limb are not well understood in regard to functional testing.
The importance of short-day vernalization is not well understood with regard to variation in anthesis time.
The impact of environmental factors, for instance the location and modality of dialysis, are not as well understood in regards to the extent to which they influence medication adherence [ 59, 60].
Finally, while the maintenance of DNA methylation during replication is fairly well understood, many questions remain regarding the maintenance of histone methylation on newly-synthesised chromatin.
