Although functions of proteins in these families are not well understood, expression studies of sg C genes in the mycoparasitic fungi Trichoderma virens and T. atroviride suggest roles in morphogenetic development and exogenous chitin degradation (Gruber et al. 2011; Gruber and Seidl-Seiboth 2012).
The mechanisms controlling AQP5 expression are not very well understood, but expression of AQP5 has been correlated with methylation levels of its promoter, with a reduced expression when the promoter was highly methylated [ 11– 13].
To further assess the underlying cellular and pathway representation of the identified RA synovial phenotypes, we examined the expression of genes with well-understood biological function that showed differential expression across the RA phenotypes.
Factors controlling dedifferentiation in newt limb are not well understood; however, expression of the muscle segment homeobox gene msx-1 is induced in the blastema [20] and also in regenerating amputated mammalian digits [21], suggesting a role in dedifferentiation.
While the physiological roles of HIC are not yet well understood, its expression, like that of its Xenopus ortholog XIC, appears to be under tight control [42], [48] (Q. Wang et al., unpublished results).
Though not well understood, the altered expression of apelin we observed in the diabetic heart in response to rosiglitazone may present a novel pathway for the study of diabetic cardiomyopathy.
Despite our knowledge of the regulatory mechanisms affecting transcription, it is not well understood how the expression levels of transcripts correspond to downstream protein abundances.
Down-regulation of claudins in cancer seems to be well understood, but increased expression of claudin contributing to neoplastic progression is less clear [ 1].
Because the role of VEGF189 and VEGF206 in vivo is not well understood and their expression is low compared to VEGF121 and VEGF165 [ 3], we consider the two main isoforms VEGF121 and VEGF165 in our model.
As a vocal artist she understands expression too well to be limited by any one style: she can give you classical purity that makes vibrant the clear simplicity of Ives's "Serenity," and then turn around and belt in "The Real American Folk Song (Is a Rag)" by Gershwin.
The public knows the expression well understands that it means then and not now.
