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Long-time climate change skeptic Patrick Michaels testified before the House Science and Technology Committee and misrepresented the scientific understanding of the human role in climate change and the well-understood effects of fundamental climatic factors, such as the effects of visible air pollution.
In contrast, the initially less well-understood effects of STAT3 inhibition on endothelial cell function raised concerns regarding a possible aggravation of endothelial and vascular dysfunction which might rather increase the numbers of major adverse cardiac events.
Two well-understood effects of Rad53 activation are the inhibition of late origin firing during S-phase (Zegerman and Diffley 2010; Lopez-Mosqueda et al. 2010) and prevention of sister chromatid separation in anaphase (Sanchez et al. 1999; Agarwal et al. 2003), both of which allow time for DNA repair to occur.
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Additionally, by comparing the data-to-model predictions from constraint-based approaches such as FBA, MOMA and RELATCH we demonstrate the important role of less well-understood kinetic and regulatory effects in central carbon metabolism.
Thus, an ideal platform for pathogen detection would pair the broad virulence mechanism array with a resequencing array for specific virulence genes, whose polymorphisms have well understood effects on virulence or drug resistance.
The basis of this effect is not well-understood however, even though it reduces yield of crops injured by herbivory, and produces dramatic effects exemplified in ornamental bonsai plants.
Changes in runoff resulting from heterogeneous wildfire effects are not well-understood due to both limitations in the field measurement of runoff and temporally-limited spatial data available to parameterize runoff models.
This improves clarity, as the effects of frequency selectivity are well-understood [15] and are not necessary for a first investigation of CARA.
Indeed, our review demonstrates that the effects of woodland reduction are well-understood for only a subset of taxonomic groups (e.g. birds and small mammals); whereas other groups (e.g. reptiles and terrestrial invertebrates) are consistently under-studied.
The effect of temperature rise is not well-understood, though some evidence is available.
Even though viral inactivation due to the use of low pH product elution buffers is relatively well-understood (Brorson et al., 2003b), the low pH effect on LRV is still not clear.
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