As we approach yet another extended deadline to sign a deal with Iran, the negotiations focus on the well-known problematic issues such as sanctions relief, inspection of military facilities, nuclear history, number of allowable centrifuges, reduction of nuclear fuel and keeping nuclear facilities.
These inconsistencies may have arisen from the well-known problematic nature of BDNF immunohistochemistry or from the fact that BDNF is generated as a pro-protein from multiple RNA splice variants.
Take, for example, one of the most well-known and problematic phenomena of the shadow banking world: structured investment vehicles, or SIVs.
Sequences in Onychophora are extremely A + T rich to a degree that is comparable only with those of the well-known compositionally problematic ticks and nematodes (supplementary table 1, Supplementary Material online).
We applied the RGC_CAM approach to a well-known case of problematic phylogeny, namely, the evolutionary positions of the slime mold D. discoideum (member of the phylum Mycetozoa or social amoebae) and E. histolytica, member of the phylum Archamoebae.
Type theory has never gained unanimous consensus and its many problematic aspects are well-known (see, e.g., Fitch 1952, Appendix C; Bealer 1989).
However, though this is perhaps the most natural way to interpret de re modal statements (once it has been accepted that the apparatus of possible worlds is to be used as an interpretative tool), there are well-known difficulties that make the approach problematic.
We acknowledge that relying solely upon voluntarily reported events may be problematic due to the well-known issues of reporting bias, volume, seasonality, and anonymity concerns [ 30].
Potassium and calcium were used since it is well-known that these elements play important roles in biomass ash chemistry, where potassium is considered problematic and calcium may remedy ash-related problems.
Nevertheless although well-known this comparison, let alone to any other extant group of echinoderms [10], [46], [47], remains highly problematic.
The complex interaction between patients admitted to chronic- and acute-care facilities is well-known, and the resulting "import" and "export" of MRSA is of great concern (25), making MRSA outbreaks problematic.
