The optical texture shows an array of parabolic focal conics (PFCs), which are well-known defects characteristic of a smectic-A layer structure in thermotropic LCs35.
The authors have proposed a very interesting voting method to remedy the well-known defects in standard methods, such as plurality voting.
Infection of cells stably expressing integrin-beta1 variants with well-known defects in fibronectin fibril formation or FAK signaling also exhibited severe deficiencies in Cdc42 activation and bacterial invasion.
But it has a well-known defect: Some of its benefits end up flowing not to workers but to employers, in the form of lower wages.
The most well-known genetic defects related to hereditary thrombophilia are mutations of factor V Leiden (FVL) and prothrombin G20210A (PT) [ 2, 3].
The most well-known metastable defect is EL2 (arsenic antisite), a native deep-donor defect in GaAs2,3,4,5, but such defects have also been found in GaN epilayers6,7 and other semiconductors such as silicon8 and InP9.
A well-known structural defect is the chimerical link problem. Figure 1 displays an example of chimerical links caused by sequencing error in string graph.
Might it be, for example, that the well-known trafficking defect seen with ΔF508 CFTR is, at least in part, a reflection of thermal instability apparent in a channel function assay, a thermal instability that might be lacking in the normally trafficked G551D channels?
The difficulty of eradicating memory of powder particle interfaces in UHMWPE for bearing surfaces for hip and knee replacements is well-known, and 'fusion defects' have been implicated frequently in joint failures.
Most of Suetonius' writings were antiquarian, dealing with such subjects as Greek pastimes, the history of Roman spectacles and shows, oaths and imprecations and their origins, terminology of clothing, well-known courtesans, physical defects, and the growth of the civil service.
The imbalance between ISGs and other molecules might be of great immunological relevance concerning the well-known DS haematological defects.
