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In this model, serum estradiol remains at a physiological level [ 16– 18] allowing us to investigate the effects of PRL excluding the well-known actions of high amounts of E2 on mammary carcinogenesis.
A novel pharmacological approach targeting MP production and properties could therefore be used to treat severe sepsis in addition to other well-known actions of APC via direct interaction with the cells of interest.
Although a mechanistic explanation for this synergism remains to be determined, isoflurane - in addition to its well-known actions at the GABAA receptor - also competes for glycine at the NMDA-receptor glycine site [ 31].
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Indeed, 11KT, besides its well-known action in fish spermatogenesis, has been demonstrated as controlling oocyte growth, likely through lipid accumulation in eel [ 83] and in atlantic cod [ 84].
Prostaglandins have well-known emetic actions [ 121].
However, it is also well-known that actions documented in patients files are not always performed [ 53].
The mechanism of dyclonine's well-known anesthetic actions is through inhibition of sodium channels (37), though the concentrations were not readily available in literature.
There is often a sizeable discrepancy between peoples' self-reported knowledge, values, attitudes and intentions, and their observable behaviour examples include the well-known 'knowledge-action gap' and 'value-action gap'.
In this design, we take advantage of the well-known capillary action that holds wetting liquid in porous media.
EPO is a growth factor exerting effects at diverse targets in addition to its well-known classical action to stimulate erythrocyte production.
Treatment safety: Regarding patient safety, the use of alprazolam, a well-known, low action, nervous system depressant drug, at minimum doses, even when no symptoms palliation is required, guarantees good tolerability, and no drawbacks are expected as a result of direct effects.
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