"Previously well-founded assumptions are being challenged in this market," Mr. Egan said.
Apparently well-founded assumptions may result in large approximation errors [ 5].
Under the well-founded assumptions that cohort B included some (possibly the same proportion of) deceased patients and that these might have similar characteristics as the excluded deceased patients (older, higher tumour stage), it is obvious that the detected and shown differences between participants and non-participants might be statistically more preponderant than in (clinical) reality.
Preliminary working hypotheses can be discussed, but well-founded homology assumptions remain more often than not elusive.
Miller, while registering some well-founded concerns about the assumptions and beliefs surrounding the military campaign, says: "We're clearly not yet on the verge of plunging into another pointless Americanasaurus charge much like the 2003 invasion of Iraq".
Are the assumptions well-founded or could other developments be assumed just as well?
The rationale for this assumption is well-founded; recent trials (GLOW1-2) [ 29] and indeed SPARK [ 20], as well as network meta analyses [ 30, 31], have shown comparability in terms of the effect on FEV1 between tiotropium and glycopyrronium and other LAMAs.
These endeavours are based on the well-founded – but empirically not sufficiently verified – assumption that participation of well informed patients and their representatives in decision-making processes would improve the different levels of health care [ 7].
These are the basic, ungrounded entities.[34] Suppose one now adds a third assumption that there is a well-founded ontological dependency structure within the domain of concrete objects.
However, this assumption may not always be well-founded: the protein fragment has been removed from its native full-length protein and removed from its native operating environment, both being dramatic changes from its normal context.
