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Other well-founded associations include the effect of high β-defensin copy number on psoriasis (Hollox et al., 2008; Stuart et al., 2012), the effect of CYP2D6 copy number on drug metabolism (Zhou et al., 2009) and the role of α-globin copy number in α-thalassemia and protection against severe malaria (May et al., 2007).
SNPs with well-characterized function do not generally have the same requirement for adjustments for multiple comparisons due to a well-founded a priori hypothesis of their potential association with a cellular function.
However, the main candidate gene, well-founded in the literature, was MRP2, while associations with U-Hg for the other genes evaluated were plausible but less well supported.
Well, the thesis is associated with the claim that grounding is well-founded.
Her fear is well-founded.
It's well-founded.
The fear is well-founded.
His confidence appears well-founded.
"Both positions are well-founded.
Her concerns are well-founded.
Such fears were well-founded.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com