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Among these the inhibitory effect of organotins such as the tributyltin chloride and triphenyltin hydroxide, cadmium salts and arsenic-containing compounds are of particular interest, due to well-established linkages to endocrine disruption via activities with other nuclear receptors including PPARy and ER.
Such companies usually have well-established linkages with universities though universities are mainly seen by them as a source of new employees, and not partners for R&D.
BCCR, established in 1969, maintains a high quality database, consistently recording more than 85% of all cancer cases in the province, and has well-established linkages with BC Vital Statistics database to capture death data.
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Therefore, important questions are raised regarding pigs given their well-established linkage in the evolution and ecology of influenza viruses.
These compounds, which are produced naturally by livestock and eliminated in urine and feces, are potent EDCs and have a well-established linkage with the development of intersex and other reproductive dysfunctions in exposed aquatic organisms.
This is of even greater importance when newly-established datasets and linkages are used, which is in contrast to the well-established datasets and linkage protocols used by the CHeReL which generated the linked data for this study.
Western Australia was chosen for this study because of its unique position in Australia of having a well-established health data linkage system that includes both hospital and RAC data [ 19].
Better linkage with well-established regulatory authorities (The Orthopaedic Data Evaluation Panel and the Medicines and Healthcare products Regulatory Agency) and the use of Patient Reported Outcome Measures can make this process more effective.
Finally, they drew on the well-established methods of genotyping and linkage analysis to identify stretches of similar DNA shared by breast cancer patients in a family.
Previously, we tested some well-established indirect tests of recombination (linkage disequilibrium vs. distance using D′ and r, Homoplasy Test, Pairwise Homoplasy Index, Neighborhood Similarity Score, and Max χ) on sequence data derived from the only empirically confirmed case of human mtDNA recombination thus far and demonstrated that some methods were unable to detect recombination.
This paper describes the detailed process of event linkage and compares directly an event-based linkage method for identifying transition events between two care sectors in Australia with a well-established high quality longitudinal person-based linkage which facilitates identification of event data for individuals.
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