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A lack of information on external validity items and well-defined outcomes can lead to difficulties in extrapolating the results of a study to other MO-patients with forearm deformities.
IHS criteria or other definitions that generally conformed to IHS diagnostic criteria were used for the diagnosis of MM in all trials, and well-defined outcomes were reported for the efficacy and tolerability.
How might chromatin remodelers achieve the sophisticated gymnastics and regulation that seem necessary to achieve such well-defined outcomes?
Therefore, to improve the management of ITP there is a need for clinical trials with well-defined outcomes to assist with the development of evidence-based treatment guidelines.
Carefully designed alumni surveys with well-defined outcomes and impact, using triangulation of information from peers and employers, seem to offer a promising approach as well.
Comparison of well-defined outcomes, such as (singleton or term) live births per started treatment strategy rather than per treatment cycle, should also be considered.
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As complex as an open-source project may be, it is also based on a single, well-defined outcome, and an engineering task that is generally free of concepts like fairness and justice, about which people can debate endlessly.
Our objective is not the prediction of a well-defined outcome, but rather of the future similarity between treated patients and a population of healthy people.
Essential to measurement is the construction of the task and its categories, which are used to compare, classify and identify ability through performance in relation to a well-defined outcome space (Humphry & Heldsinger, 2007; Wilson, 2005).
However, this concern is mitigated somewhat by relatively small total number of trials and fairly well-defined outcome measures.
The carcinoembryonic antigen (CEA) Second-Look Trial was a well-planned and carefully executed study with a clear question and a well-defined outcome of interest.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com