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(A simple analogy helps see how such a thing is possible: betweenness on a curve, but not 'up' is a well-defined concept in Euclidean space).
'Root cause' is not a well-defined concept, and I will suggest describing it in relation to what has been the normal causal context for a longer period of time.
Bets placed during the HGP over how many genes would be discovered, as well as surprise expressed when far fewer than the original estimate were found (about 25,000 30,000 rather than 100,000 the rice genome apparently has more genes!) (Normile and Pennisi 2002; Pennisi 2003), suggest that "gene"—a term introduced by Wilhelm Johannsen in 1909 names a well-defined concept.
However, ethnicity is not a standardized, well-defined concept.
The lead time for an individual PSA detected case is a well-defined concept.
The second measure of financial burden, impoverishment due to OOP, is also a well-defined concept.
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Strategically, many of her corporate staff have become concerned that the company's major expansion into China is moving too far from Levendary's well-defined concepts of store design and menu.
When applied to urban social science, it breaks down into a small number of more specific and equally well-defined concepts.
The formulation and comparison of potential energy solutions in different contexts at different scales of analysis demands well-defined concepts and robust decision support tools.
It is important to have well-defined concepts in order to avoid possible ambiguities and, therefore, impact the adaptation factor.
The operationalist dictum could be phrased as follows: maintain and increase the empirical content of theories by the use of operationally well-defined concepts.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com