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It is particularly important to ensure that judgmental areas such as nonGAAP reporting disclosures are well-defined, supporting calculations are well-documented, and that the definitions and calculations are consistent across reporting periods.
To ensure a well-defined statistic in the calculation of fold-change, pseudocounts of +1 were added to every numerator and denominator as a way to not bias differentially expressed genes toward lowly expressed transcripts (Klattenhoff et al., 2013).
In the early stages, searching and indexing can be performed on the chemical subject of the calculations, and well defined calculation meta-data.
It is an example of an algorithm, a step-by-step procedure for performing a calculation according to well-defined rules, and is one of the oldest numerical algorithms in common use.
This calculation uses the well-defined structure of microtubules (Howard, 2001) to estimate the total number of tubulin subunits within the spindle.
In most cases it is even possible to perform ab initio breakthrough calculations for a well-defined carbon bed.
Our power calculations rely on a well-defined phenotype that can be measured without error.
This means that general practitioners have well-defined denominator populations, which in turn allows the calculation of accurate disease prevalence and treatment rates.
Well-defined protocols are provided for communication between the different Calculation Units and the PUPIL system.
Results of these calculations suggest that there may indeed be well-defined rules for nanotubes.
Analysis modules and on-the-fly elementary step diffusion rate calculations can be implemented as plugins following a well-defined API.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com