Several of these critical residues (Arg45, Glu56 and Asp228) are not conserved in AtOCD nor in human mu-crystallin which has a different, although not well understood, function than bacterial OCDs.
Many C-type lectins found on cells in the immune system have been reported to initiate intracellular signalling, but this remains the least well understood function of these receptors.
By using standard gene sets and only allowing the removal of annotations, the computed enrichment results can be directly interpreted in terms of widely known and well understood genomic functions.
On the other hand, translation may be affected by RNA secondary structure which, like splicing, mRNA stability, or other less well understood RNA functions, may be significantly altered by single-nucleotide changes.
Particularly well understood are functions of nuclear FGF-R1 that, via its interaction with 90-kDa ribosomal S6 kinase (RSK1), activates the transcription factor CREB, thus regulating the transcription of genes involved in proliferation and differentiation.
Although the crucial role of DGRs in phage tropism switching is well understood, the function of these elements in bacteria is still unclear.
Pseudogenes arise in the A. phagocytophilum genome by mechanisms that are not well understood and function by being shuffled into an expression cassette using the nonreciprocal RecF pathway [15].
While the role of three of these proteins in mitigating DNA damage is well understood, the function of AidB is less clear.
However, the precise role of collagen in nonrespiratory lung function is not well understood, in part because of the difficulties inherent in studying lung collagen, regardless of the type of assay used.
It is well understood that cellular functions are carried out using various specialized groups of molecules interacting via intricate networks.
