Although the crucial role of DGRs in phage tropism switching is well understood, the function of these elements in bacteria is still unclear.
While the role of three of these proteins in mitigating DNA damage is well understood, the function of AidB is less clear.
Particularly well understood are functions of nuclear FGF-R1 that, via its interaction with 90-kDa ribosomal S6 kinase (RSK1), activates the transcription factor CREB, thus regulating the transcription of genes involved in proliferation and differentiation.
Although their fundamental biochemical properties are now well understood, aspects of TRP channel function in specialized cell types [ 2] and the potential importance of channelopathies remain incompletely characterized [ 3].
While the regulation of YAP/TAZ by MST/LATS kinases is reasonably well understood, the nature of factors functioning upstream of MST/LATS is yet to be elucidated in detail.
The natural history of all subtypes of MLD is not well understood, but deterioration of gross motor function is a key feature and progression can be rapid [6].
While the function of ribosomes is well understood, the details of how they work are not, and Demirci hopes his work at SLAC will supply new insights into the timing and chronology of ribosomes at work.
Although several studies have shown that histone acetylation and activator-dependent recruitment of Swi/Snf regulate its function, it is less well understood how subunits regulate stability and function of the complex.
The mechanism that recruits microtubule plus ends to the posterior pole at stage 9 is not well understood, but depends on the function of the conserved polarity kinase PAR-1 [5, 6].
Predicting fluid flow in naturally fractured rocks under production or fluid injection requires that permeability of a single, rough-walled fracture be well understood and accurately described as a function of the effective stress.
