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The results of V325 and REAL-2 trials, which indicated high efficacy and well tolerability of triplet regimen as the first line treatment of advanced gastric cancer, were referred to in deciding the dose of each chemotherapy agent.
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Again, this lends support to the good tolerability of SCOUT as well as to the concept that further alternate lines of chemotherapy are still possible after SCOUT.
Analysis of the results of the global tolerability assessments by the investigators and patients/parents revealed that the treatment was well-tolerated (tolerability rating of "good") or very well-tolerated (tolerability rating of "very good") in the vast majority of cases for both the FAS and PPS (see Table 5).
This study was designed to study clinical and bacteriological efficacy as well as tolerability of ceftiaxone + disodium edtate + sulbactam (the novel Antibiotic Adjuvant Entity; Elores) in adult patients in the treatment of lower respiratory tract infections (LRTIs) and urinary tract infections (UTIs).
Lyketsos and colleagues (2004) assessed the long-term efficacy as well as tolerability of galantamine.
However, considering the well-established tolerability of metformin, its potential HSC-mediated effect on angiogenesis merits further investigation.
Dasatinib appears to be generally well tolerated, regardless of disease phase, and long-term tolerability data are eagerly awaited.
After 7 days of observation, patients were asked to evaluate the success as well as the tolerability of their chosen therapy using a 5 point Likert scale.
In the palliative phase of disease management, quality of life and the disease- and symptom-free period are of great importance, as well as the tolerability of the drugs used.
These have demonstrated an increased prefrontal perfusion after a single dose of DHX in schizophrenia patients as well as a good safety and tolerability of a daily 20-mg single dose, although without any improvement in cognitive performances [ 157, 158].
Overall, esomeprazole 40 mg and 20 mg were well tolerated, displaying similar tolerability profiles to placebo over 26 weeks of treatment.
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