In 2008, Lu and Wang developed a coarse grained two-well model to study the conformational dynamics of ADK in microscopic detail [ 19].
Mice deficient in the telomerase gene products are well established and potentially very good models to study the pathogenesis of telomerase-related bone marrow failure, as already reported [50].
Moreover, PC3 are a well established model to study Eph-ephrin pharmacology whereas HT29 cells are commonly used to study the physiological role of bile acids [20].
Recently, we performed yeast chronological ageing experiments, a well established model to study oxidative damage and ageing in post-mitotic cells [49], [50], and demonstrated that α-Syn-mediated toxicity correlated with enhanced levels of reactive oxygen species (ROS) produced in the respiratory chain in mitochondria and, as such, with signs of apoptotic and necrotic cell death [32], [37].
Among these groups, fig wasp is a well known model to study male polymorphism [ 16- 25].
The LAR is therefore a well validated model to study inhibition of allergic inflammation, which supports the prediction of clinical efficacy.
Core histone gene is a well-established model to study eukaryote gene transcription regulation mechanism.
To test epidermal keratinocyte proliferation, we employed a skin equivalent culture system, which is a well-characterized model to study the interaction of epidermal keratinocytes and dermal fibroblasts (Boelsma et al., 1999; Pickard et al., 2012; Ridky et al., 2010).
We selected the so-called inflammatory soup (IS) as activating stimulus, which is a well-established model to study the mechanisms underlying the sensitization of trigeminal primary afferent neurons.
However, the pseudo-first-order and pseudo-second-order kinetic models are the most well-liked model to study the sorption kinetics of dyes and have been widely used in the kinetic study of dye sorption using various kinds of sorbent materials (Chowdhury and Saha 2010b).
Zebrafish is a well-established model to study the dynamic processes of gastrulation cell movements [29].
