Although the markers were selected as SD markers segregating 1 1 in the progeny a chi square value was used that allowed inclusion of SD markers with moderate segregation distortion (skewed SD markers) but excluded likely double dose markers as in [ 23], as it is well known that segregation distortion is common in plants.
The resulting plate had a well defined manganese banding pattern with a known segregation bandwidth.
Similarly, C. botulinum is well known to for its segregation on the basis of a wide range of neurotoxins produced by them [ 16, 28, 67].
It is well known that most mechanisms that affect segregation distortion act in the male gametes and affect male fertility [24].
Plasmid segregation is a well known phenomenon in recombinant DNA biotechnology and major factor reducing the yield of recombinant proteins [ 1- 3].
Tyrosine recombinases of this type are well known to be involved in chromosomal segregation, as with E. coli XerC and XerD [ 64] or the resolution of recombinational dimers, as with the Cre protein of coliphage P1 [ 65].
The molecular regulators of early lineage segregation in mouse embryos are well known but those in pig embryos are not.
This is in contrast with previous experiments in which trypanosomes treated with okadaic acid (OA), a well known inhibitor of PP1 and PP2A enzyme activity, show defects in cytokinesis and organelle genome segregation (multinuclear cells with single kinetoplast) [ 85].
Up-regulation of these mitotic kinases was not surprising, because it is well known their involvement in tumourigenesis, considering also the central role of the phosphorylation in mitotic checkpoints, spindle function, and chromosome segregation.
It is well known that the cell cycle is composed of two consecutive periods, characterized by DNA replication, and of sequential differential and segregation of replicated chromosomes into two separate daughter cells.
Well, not too well known.
