It appears that while the utility of glyphosate application for male gametocidal action is well known, the implications of this effect regarding gene flow in the environment between compatible species remain understudied.
Several with known implications in ccRCC development, like the upregulated miR-21-5p, miR-142-5p, as well as the downregulated miR-106a-5p miR-106a-5p miR-106a-5p6.
The environmental and economic arguments for all countries to reduce their emissions are relatively well known; the security implications are becoming more apparent and are increasingly being considered by countries like the United States, the United Kingdom and our partners around the world.
Less well known are the implications of hibernation to many metabolic diseases, by comparing the known molecular changes in hibernators to those observed in obese and diabetic phenotypes in humans [10].
Their impacts on the space systems are well known, while their implication to the underlying interactive processes in the atmosphere-ionosphere system is a subject of active investigation.
This gene, well known for its implication in Duchenne muscular dystrophy in Human through mutations leading to loss-of-function of the gene products in striated muscles [ 71], is also expressed in the brain, where it might account for the mental deficiency reported in Duchenne muscular dystrophy patients (see [ 72] for a review).
Abraham Lincoln's "depressive episodes" are well known, and their political implications have been the subject of thoughtful extended treatment, most recently by Joshua Wolf Shenk in "Lincoln's Melancholy".
This event is also well known for its practical implications.
The importance of detritiation of heavy water from CANDU-type reactors is well known, as is the implications of detritiation in fusion processes and installations.
Fibroblast Growth Factors (FGF) and their receptors are well known for having major implications in cell signalling controlling embryonic development.
It is well known that the converse implication of (Cont → Bro) does not hold.
