A well known down-stream target of p53-activity is the pro-apoptogenic factor Bax [11], [24] and, moreover, Bax has been implicated in the formation of mitochondrial channels that are involved in the release of apoptogenic proteins.
It is well known that Down syndrome and Turner syndrome cause cataract as an eye complication.
A maternal age effect is well known for Down syndrome, which is most commonly caused by three copies of chromosome 21, with the extra copy usually of maternal origin (Crow, 2000).
Mr. Edwards had built his career by choosing a side and not relenting; he was well known for turning down big settlement offers because he was confident he could win his case.
It is well known that Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically.
Some are well known: taking down the boards of rival agents, or accepting bribes from low bidders not to tell sellers about higher offers, for example.
A well known scaled down sample system data has been selected for studies and the controllers designed have been tested for worst conditions.
The themes of sacrificial father/son relationships, of inherited sin, of the burden of history, and of the centrality of the "individual, human existence relationship, the old text, well known, handed down from the fathers" (Postscript) are repeated many times in Kierkegaard's oeuvre.
Maher understands the mechanics of comedy much too well not to have known down to his very core that there was no conceivable payoff that could be worth using that term.
It is well known that patients with Down syndrome are at an increased risk of not only malignancy, but also Alzheimer's disease and adverse drug reactions to many chemotherapeutic agents, including MTX.
