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The relatively small sample size (n = 42) of the primary infection cohort reflects well known challenges in identifying acutely infected individuals which include but are not limited to a lack of specific clinical signs and symptoms, and the extremely short time period preceding seroconversion.
There are a number of well known challenges, for example, to PRO data collection, appropriate timing of assessment, adequate statistical analysis and outcome interpretation [ 9, 10].
The assembly and analysis of short-read sequence data presents a number of well known challenges including error correction, correct determination of repetitive regions, and accurate identification of genetic variation such as single nucleotide polymorphisms (SNPs) and insertions/deletions (indels).
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Using the proof planner of the Ωmega system we were able to solve all the well known challenge theorems including those that cannot be solved by any of the existing traditional systems.
This is a well known challenge in qualitative studies where every shade in the language is important, and therefore the ability to use your mother-tongue is crucial.
Another well known challenge in observational studies is the risk of bias due to confounding, which in our study could have occurred in terms of factors other than the QIC causing the observed changes.
The useful implementation of this concept, however, faces a number of well know challenges.
Delayed onset of efficacy of antidepressants and a high proportion of depressed patients being poor or non-responders to antidepressants are well known clinical challenges.
So, I asked two people who are well known for challenging and countering the views of climate sceptics to suggest their own additions.
We propose a new approach to addressing well known issues challenging identification of any patent effect: firm heterogeneity, simultaneity between firm performance and patenting, and sample selection.
He believed in equality of opportunity for all people and is well known for challenging the iniquities of the rigid British class system of the 1930's.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com