In view of the prospective mortality results, pre-frail, as well as frail, subjects should be considered, regardless of age, for further assessment.
As friends and relatives yesterday mourned the death of Hollywood actress Brittany Murphy, fragments emerged about the last weeks of her life, marred by personal and professional humiliations which included her abrupt exit two weeks ago from a film set in Puerto Rico, as well as frail health.
The elder Richardson, whose work has graced the pages of Harper's Bazaar and French, Italian and British Vogue, is pictured at turns as both handsome and confident as well as frail and guarded in Terry's photos.
This is a general problem in insurance claims data, but in our view, the benefits of claims data outweigh their disadvantages: We are provided with a large unselected population, representing real-world conditions and including persons living in protected institutions/nursing homes as well as frail individuals and the oldest olds, all frequently not included in survey and field studies.
Finally, although the frailty risk increases with age, the population of 70+ patients is probably highly heterogeneous: both well and frail patients with various chronic diseases are included in each age-group.
Although speculative, taken together, these findings suggest that patients without HbA1c measurements represent a heterogeneous group comprised of misclassified patients, those with very mild disease, as well as frail older patients not being actively managed for their diabetes.
In contrast, very old (>80 years) as well as frail people were able to maintain the ability to metabolize CYP3A4 substrates in a phenotyping study using the erythromycin breath test (ERBT) [ 5].
Throughout this development, future users, i.e. primary care professionals and geriatricians (n = 15), as well as (frail) older people and informal caregivers (n = 14), were involved extensively trough their participation in working groups.
Her mother had undergone cataract surgery in 1955, and she did not recover well, becoming frailer and ever more demanding until her death, in 1966.
So if observers in Vatican City say Benedict looks frail, well, maybe he is.
