Sentence examples for well established type from inspiring English sources

Using the well established type 2 diabetic animal model db/db mice, we observed a dramatically enhanced LA responsive mitochondrial Ca2+ efflux and protein nitrotyrosylation in the kidney.

The present study is a comprehensive evaluation of joint effects of the four most well established type 1 diabetes susceptibility genes in both a large case-control series and family material.

To investigate whether the better glucose tolerance phenotype in the offspring of long-lived individuals is due to lack of genetic variants associated with type 2 diabetes, we analyzed 15 well established type 2 diabetes variants in the Leiden Longevity Study [ 13] for their association with familial longevity.

Because type 2 diabetes is the predominant form, comprising more than 90% of patients with diabetes, and because its association with premature coronary artery disease is particularly well established, type 2 diabetes is the focus of this article and was the focus of the journey from the bench to the bedside that it addresses.

Type 2 diabetes is also a common disease, and it is well established that type 2 diabetes is associated with a higher risk of colorectal cancer (4– 8).

Moreover, our findings provided evidence for a potential mechanism to explain the antiproliferative effects of type I IFN in certain cell types, considering that autophagy is often concomitant with cell cycle arrest and senescence., It is well established that type I IFN mediates signaling primarily through the JAK-STAT pathway.

The relationship between increased arterial stiffness and cardiovascular mortality is well established in type 2 diabetes.

It is well established that type 2 diabetes is a risk factor for cardiovascular disease.

Although its prognostic value for myocardial infarction is controversial in the general population (11, 12), its impact for renal prognosis is well established in type 1 diabetes (13– 13).

Abnormal electrical propagation, reflected as prolonged QRS and QT interval, as well as an increased risk of sudden cardiac death, is well established for type 2 diabetic patients (reviewed in [ 24]).

Prospective studies have observed an association between overweight and overall mortality (Lew and Garfinkel, 1979; Manson et al, 1995; Calle et al, 1999), and several adverse health consequences of elevated body weight are well established, including type II diabetes, hypertension and coronary heart disease (Must et al, 1999).