When this trial was designed, these data were not well established and the weekly D schedule was chosen because of its low toxicity profile.
Adverse effects were observed in the initial studies when the dosing schedule was not yet well established and the higher frequency of administration of TU led to higher-than-normal levels of testosterone.
The high immunisation coverage may be explained by the fact that immunization schedules are globally fairly well established and therefore conducted more consistently across the sites.
The Positive and Negative Affect Schedule (PANAS-X) is widely used with well established psychometric properties [ 37].
However, optimal dosage and scheduling in infants and children is currently not well established.
We therefore decided that, while evaluating these drugs in gastroesophageal cancer patients, we would take the opportunity to explore a different schedule, modelled on the attractive 2-weekly FOLFIRI regimen now well established in colorectal cancer.
However, principles for determining training-schedule design for efficient utilization of these systems are not well established.
Most are well established.
The facts are well established.
All this is well established.
