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Molecules with well established roles in this process include cell adhesion molecules [60], Ephrin ligands and Eph receptors [61], and the classical cadherins [62].
The nuclear hormone receptor peroxisome proliferator activator (PPAR) β/δ has well established roles both in metabolism and in the skin.
miRNAs regulate various biological processes and have well established roles in cancer [ 1].
This is completely consistent with our expression analysis results since the WRKY family of TFs [ 60] have well established roles in regulating disease responses in plants [ 61].
Two of the proteins, IL1A and CD86 have well established roles in immune response (Cytokine signaling and T-cell receptor signaling).
The sterol metabolic process pathway contained several genes with well established roles in cholesterol metabolism, including 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) and sterol regulatory element binding transcription factor 1 (SREBF1).
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Plant hormones such as ABA, SA, MeJA, and ethylene have well-established roles in modulating plant signaling networks [ 40].
Using genetic approaches, we show that proteins with well-established roles in ERAD-type degradation contribute to the degradation of PGP-3ΔF508 PGP-3ΔF508ans.
ADP-ribosyltransferases (ADPRTs) form an interesting class of enyzmes with well-established roles as potent bacterial toxins and metabolic regulators.
Intermediate states play well-established roles in the folding and misfolding reactions of individual RNA and protein molecules.
Given the well-established roles of cadherins in morphogenesis and differentiation, LI-cadherin may be a key factor mediating CDX2 function in intestinal cell fate determination.
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