Sentence examples similar to well established release from inspiring English sources

Climate change is of growing international concern and it is well established that the release of greenhouse gases (GHG) is the driving factor (IPCC, 2006).

It is well established that the release of leukocytes, and particularly neutrophils and monocytes, is stimulated by inflammatory mediators, such as IL-6 (Suzuki et al. 2003; Nieman 1997).

Time-dependent receptor desensitization is well established for gonadotropin-releasing hormone (GnRH), which is, at normal pulsatile low concentrations, required for fertility.

It is well established that ATP, released in response to stretch, acts on afferent nerve P2X2/3 receptors, playing a sensory role in the micturition cycle and also nociception in pathological states [ 20].

It is well established that Leishmania releases virulence factors that promote parasite survival in macrophages, so we tested whether L. mexicana MCA is secreted and thereby modulates functions of the host cell to promote Leishmania replication.

Until now it has not been investigated whether pancreatic ducts release ATP, however, it is well established that ATP is released from pancreatic acini, which store ATP in zymogen granules, where it is accumulated by the Vesicular NUcleotide Transporter (VNUT, SLC17A9) [ 33].

It is well established that necrotic cells release strong pro-inflammatory molecules such as DNA and high mobility group box protein-1 (HMGBP1) (Jaeschke et al. 2012b).

Human transport to relatively disturbed urban areas thus became the decisive factor to induce parasite release, a well established general promoter of invasiveness in non-social animals and plants, but understudied in invasive social insects.

As a measure for caspase-1 activation, we used two well established assays: i). the release of lactate dehydrogenase (LDH) which occurs upon caspase-1 activation [31], [32], [33], [34], and ii). the secretion of mature IL-1 that was measured in a bioassay as described previously ([29]; Fig. 1B and 1 C, respectively).

This complex interaction can be illustrated by a well established double paracrine mechanism: NHKs release IL-1 [21], [29] [30]]–[30] and or parathyroid hormone-related protein (PTHrP) [21], [31] to induce the expression of growth factors such as KGF, GM-CSF and IL-6 in HDF, which in turn regulate both NHK proliferation and differentiation [21], [30].

The regulatory role of the hypothalamic-pituitary-adrenal axis, which can stimulate corticosteroid release, is well established.