Hopelessness is a well established predictor of suicidal ideation and intent, independently of depression [ 71– 71].
Decreased heart rate (beat-to-beat) variability is a well established predictor of cardiovascular morbidity and mortality [ 1- 4].
Socio-economic status is, in fact, a well established predictor of oral-health-related quality of life [ 22, 27, 28].
The strong performance of our method in the context of a very well established predictor of malaria resistance, Hemoglobin S, serves as a positive control (method validation), and this further suggests that the conclusions about ATP2B4 and MARVELD3 should be useful.
To obtain less biased estimates, we adjusted our model a priori for several well established predictors of placenta weight that may confound or suppress effects, including maternal age, infant sex, parity, maternal pre-pregnancy body mass index, occurrence of hypertension and diabetes during pregnancy, and smoking status, with the categories indicated in Table S1 [23], [24], [25], [25].
Clinical variables such as stage of the disease and age of the patient at diagnosis are well established predictors of neuroblastoma outcome.
Obesity and sedentary lifestyle are well established predictors of T2D [ 37, 38] and were, in this survey, strongly associated with T2D.
However, cerebrovascular disease and peripheral artery disease are both well established predictors of cardiovascular mortality [ 26] and also in this study, the score showed a strong association with CHD status.
Patients' own beliefs regarding RTW [ 22- 26], patients' ratings of pain intensity and disability [ 17, 19, 34], and the perception of constant back strain when working [ 26, 35- 37], are all well established predictors of non RTW.
Presence of psychotic symptoms[ 3, 6], lower degree of prior treatment resistance [ 7- 9] and shorter symptom duration [ 8, 10] are relatively well established predictors of response to ECT [ 11].
23 27 Increased age is among the most well established predictors of C. difficile risk, and could relate to increased frailty, immune senescence and high rates of hospital contact and antibiotic exposure, but may also be driven by an age-related reduction in the protective diversity of the gut microbiome.
