Sentence examples similar to well established plays from inspiring English sources

The trade-off here is that with the lighthearted tone so well established, the play's abrupt shift toward tragedy makes the gears of the production grind audibly.

Matrix metalloproteinases (MMPs) and 'aggrecanase' a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for development of OA therapies.

Among the viral structural proteins, M protein, which lines the inner surface of the host cell's plasma membrane, is well established as playing a key role in virion assembly.

Certainly for alcohol consumption in particular, the role of peer influence has been well established as playing an major role in encouraging excessive alcohol consumption [ 66].

Additionally, they can up‐regulate heat shock proteins (HSPs) that are well established to play a cytoprotective role in intestinal epithelial cells 17.

Signalling through the PI3K/Akt pathway is well established to play an important role in melanoma progression [ 34– 36] but to date no link has been made between MIF expression and regulation of the PI3K/Akt pathway in this setting.

The identification at a sequence level of various enzymes well established as playing a role in CIS and the discovery of several unexpected CIS-associated global expression trends provides new molecular and conceptual tools for further understanding this phenomenon.

Since TGF- β and its downstream signal transducers Smads have been well established to play a vital role in the progression of fibrogenesis at both cellular and molecular levels [ 20], we next sought to determine whether TGF β1/Smad signaling was altered in the PP2Ac α knockout mice that may underlie the inner mechanism behind its resistance to CCl4-induced fibrosis.

However, it is well established that inflammation plays a biphasic role in fibrosis; for example, the inflammatory protein TNF-α plays a biphasic role in fibrogenesis by promoting the initiation/inflammatory stage of fibrogenesis but suppressing the later, fibrotic stage of fibrosis [ 45- 49].

For example, it is well established that TNF plays a key role in RA pathogenesis and is a validated drug target of RA.

It is by now well established that curvature plays a fundamental role in the description of the topology emerging from the partially mixed structures advected by chaotic flows.