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This study presents the design and synthesis of a series of [PEG]n linked dimeric ligands of CXCR4 based on the knowledge of the homodimeric crystal structure of CXCR4 and our well established platform of chemistry and bioassays for CXCR4.
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This review aims to summarize advances in targeting lymphoma, leukemia, and myeloma through both cutting-edge and well established platforms.
Self-assembled monolayers (SAMs) of alkanethiols on gold surfaces provide well established platforms for the study of enzymatic reactions and protein ligand and cell ligand interactions and are ideally suited for our studies.
As an independent reference point, we also examined the measurement precision of Affymetrix GeneChips, a well established microarray platform.
The Berlin-based startup pivoted from online collaboration tools for learning management to MOOCs back in March last year, seeing potential to help spread the free online education phenomenon to Europe which has generally lagged behind the U.S., where the likes of Coursera, Udacity and edX are already well established MOOCs platforms.
It was an already established format on iTunes, which was, by then, an established platform.
[ 24] proposed novel biomarkers in the Whole-Blood RNA profiling, a well established diagnostic testing platform for cardiac allograft rejection and CAD diagnosis, approved by FDA and insurance coverage; Floyd et al.
Bauer is proposing to run stations on the Sound Digital platform, including Heat Radio, Absolute 80s and Planet Rock, all of which are already well established on digital platforms, and Kiss spin-off, Kisstory.
To evaluate how the fully optimised custom array setup compares with other technologies, several analyses were performed in parallel on our mouse and human MAS macroarrays and on other well established gene expression platforms.
Although the present MALDI method is highly sensitive and well established on the MSI platform, some limitations need to be overcome before the broad range of endogenous metabolite imaging can be achieved.
Significant efforts have been exerted in generating model systems to delineate the mechanism as well as establishing platforms for drug screening.
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