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Protocol and guidelines are a well established part of the neonatal intensive care environment, making sudden change in many areas a potential threat to sometimes long established local norms.
Hosking and colleagues [ 30] draw particular attention to this problem in CYP2D6 in their article on detection of genotyping errors by testing for deviation from Hardy-Weinberg equilibrium (HWE P < 0.05) and such testing is now a well established part of genotyping quality control [ 31, 32].
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For well established parts of the network (e.g. PMC), detailed data is required.
This approach has undoubtly contributed to the development of knowledge in medicine and it still constitutes the core of evidence-based healthcare [ 1], but systematically disregards also the well established parts of the corpus doctrinae which do not involve particular opinions, but just well consensued knowledge, which obviously exist.
Created in the first century B.C. by Tiro, secretary to Rome's famous orator Cicero, it was well established as part of Tiro's extensive shorthand system, the notae Tironianae, by the time the proto-ampersand arrived a century later.
During this period of time, Photo Realism was well established and part of the mainstream painting in the Bay Area.
The use of supporting resources is well established as part of effective interventions [ 6] and the LGM materials were positively received and used.
Altered gene expression gives rise to the senescent phenotype, and is well established as part of the mechanisms and pathways that activate the senescence program in cells.
The prevalence of CPC in a large population of children has not been well established, in part due to variations in the definition of CPC.
Utility of this approach to measure responses to therapy is less well established, in part due to challenges in obtaining serial biopsies.
It is well established that part of the phenotype of cancer cells is resistance to apoptosis, though the cellular mechanisms that mediate this characteristic are not fully understood.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com