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Ultimately, one may question the ability of well established outcome measures to determine the smallest meaningful change as the "true" MCID is unknown.
Because of well established outcome measures, the lipid-lowering drugs Pravastatin and Atorvastatin (serum low-density lipoprotein cholesterol, LDL-C) and the anti-glaucoma drugs Timolol and Latanoprost (intraocular pressure, IOP) were chosen for this investigation.
A particular strength of this study was that results were adjusted for the effects of fMRI task performance, as well as the established outcome moderators, age and education.
It is well established that clinical outcomes are dependent on host, treatment- and pathogen-related factors and understanding which groups benefit from one treatment relative to another is of great importance.
It is, however, well established that the outcome after SAH differs widely between individuals.
By using well established and objective outcome categories and incorporating all available clinical information we have been able to define groups of patients with either sepsis or non-infective SIRS.
The ADAS-cog is well established as an outcome measure in mild-to-moderate AD but clearly has several items that are not expected to change in early disease [ 20].
It is now quite well established that MTH improves outcome [ 2].
Specific genomic alterations, such as loss of the chromosomal region 11q or amplification of the oncogene MYCN, are well established markers of poor outcome in neuroblastoma.
Clinical variables such as stage of the disease and age of the patient at diagnosis are well established predictors of neuroblastoma outcome.
Prevention and treatment guidelines are well established for plague, but outcome of infection is improved by early diagnosis followed by appropriate treatment with antimicrobial drugs (36 ).
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