Thus, exogenous surfactant administration in neonatal ARDS-like lung injury is a clinically well established treatment option [ 1, 6, 7].
4– 10 Bisphosphonates are a well established treatment option for maintaining bone health in patients with cancer and are a standard supplemental therapy for patients with advanced cancer.
Unicondylar knee Arthroplasty (UKA) is a well established treatment option for osteoarthritis of either medial or less often lateral knee joint compartment.
It should be noted that bisphosphonates are a well established treatment option with a long history of clinical use in this patient population and have a well characterized and manageable safety profile.
Currently, there are well established therapeutic options for treating RA, namely Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Disease Modifying Anti-Rheumatic Drugs (DMARDs) that include biologic agents targeting cytokines, T lymphocytes and B cells [ 7– 9].
The established option loophole in Germany is convertible bonds.
Migration in search of employment then, is both well established as a viable option in China- including the option of undertaking sex work- and Hong Kong has been established as an attractive and feasible destination, thanks to an established sex industry, higher potential earning capability and easing of travel restrictions.
In contrast, the role of intravenous iron is well established as a therapeutic option in numerous areas, including IBD, in the adult population [ 8].
Molecularly targeted therapy with agents blocking vascular endothelial growth factor (VEGF /VEGF receptors (VEGFR)(1– 6) or mammalian target of rapamycin (mTOR)(7, 8) is well established as a treatment option for advanced renal cell carcinoma (RCC), and improves progression-free survival (PFS) and quality of life compared with cytokine therapy.
Since this is a new indication field, we represent the opinion that the monitoring of the local and systemic pharmacokinetic properties of AIBGs should routinely occur until this treatment option is well established.
As both treatment options are well established and approved therapies, one or the other would be employed irrespective of whether the patient decided to be enrolled in the study.
