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On the basis of the well established observation of immunodeficiency following trauma, blood loss and major surgery, three questions arise.
The data presented here confirm the well established observation that multiple births are at greater risk than singletons of having a congenital anomaly.
Overexpressed HER2 receptors were associated with decreased overall survival (p = 0.129; HR = 1.42 (95% CI 0.90 to 2.25), p = 0.131), a well established observation that became unambiguously evident in cases that were scored IHC 2+ and HER2 FISH positive, p = 0.024).
There is a well established constant observation between higher prevalence of all genetically transmitted disorders and consanguineous marriages [ 41].
Although the observing of selected star positions with meridian circle telescopes had become well established by observers during the 18th and early 19th centuries, the new plan called for meridian observations of all stars down to the ninth magnitude.
It is well established through field observations, experiments, and chemical models that oxidation (redox) state and pH exert a strong influence on the speciation of dissolved components and the solubility of minerals in hydrothermal fluids.
Solvatochromism though a well established phenomena, such observation is reported first time in the present manuscript in the area of helicate chemistry.
Although the mechanism of action of ECP is not well established, clinical and laboratory observations support the hypothesis of a vaccination-like effect.
Importantly, although finger movements are probably well established in the observers' motor repertoire, covert motor activation was stronger during the pause intervals than during actual action observation.
Motor cortex activation induced by movement observation is well established and existing evidence includes involvement of the contralateral primary motor cortex (Fadiga et al. 1995; Hari et al. 1998; Van Schie et al. 2008), the presumed origin of the LRP (Praamstra et al. 1999).
People prefer potential lovers to have symmetrical faces the more so they are, the better.This observation is now well established.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com