While the incidence, case-fatality and risk factors for stroke are well established, work needs to continue particularly in low-income countries, where these data remain sparse; and in relation to specific stroke subtypes such as IS.
Treatment of CHB is not well established and needs to be assessed carefully.
Interestingly, from a national innovation system point of view, this may be a well-argued position but, from a competence set point of view, well established, much needed and valuable local competences have been side-tracked more or less unintentionally.
Despite the tremendous amount of work that has been done on CREB, the epigenetic mechanisms for the regulation of gene expression via CREB and CBP interactions and its overall implications in alcoholism have not been well established and need to be investigated further.
Although infant diagnosis is well established, the need to consider HIV in acutely or chronically unwell older children has not been emphasized, leaving guardians and health providers alike potentially unaware of the high risk of HIV as the underlying cause of ill health in older children and adolescents in this region.
Now that the association is well established, future research needs to focus more strongly on disentangling underlying mechanisms.
However, the reason behind such immediate rise of the peripheral blood level of endogenous PG metabolite after cloprostenol injection is not well established and it needs further investigation.
Now that GHIs are well established, knowledge is needed on their effects across more diverse country settings, and at subnational as well as national levels.
It is well established that this need for greater space can trigger mobility and mobility can lead to ownership (Deurloo, et al., 1994).
In relation to question 1, although it is well established that we need to draw on theory to more fully understand the nature of interprofessional education, practice and care [ 18], there are only a handful of theoretical-based explanations reported in the literature about student learning within interprofessional practice-based environments.
But she's so well established now, she barely needs the award, and the panel may have felt they couldn't nominate her again without giving her the actual gong.
