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Although the efficacy of newer antidepressants has been well established for the treatment of mild-to-moderate depression, there are very few studies concerning severe depression.
It is not well established if and to what extent mild to moderate cognitive impairment predicts mortality and risk of nursing home admission after hip fracture.
Additionally, to obtain cell-derived Fn matrices, we used a well established protocol [ 21] comprising a mild detergent and multiple washing steps.
In S. cerevisiae, it is well established that mutations leading to relatively mild impairment of the multivesicular body pathway promote the recycling of the Gap1p amino acid permease from the membranes of late endosomes and vacuoles to the plasma membrane (Nikko et al., 2003; Nikko and Andre, 2007).
The ADAS-cog is well established as an outcome measure in mild-to-moderate AD but clearly has several items that are not expected to change in early disease [ 20].
Mild hypothermia of 34°C is well established to attenuate lactic acidosis and better preserve tissue oxygenation.
Diagnostic criteria for grading CTS severity as "mild" and "moderate" are not well established.
It is well established that insulin has strong metabolic effects and in addition mild promitogenic characteristics [ 14].
The benefits of rate control achieved by activating VRR function is well established in patients with chronic AF and no or only mild HF treated with a single chamber right ventricular (RV) pacing.
The EDC/NHS chemistry used to couple amine and carboxyl groups is very well established and the reactions themselves are noted in the literature as mild [13], [21].
The safety and tolerability of hydromorphone is well established, with a side effect profile similar to that of other opioid analgesics (mild to moderate constipation, dizziness, nausea, and vomiting).
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CEO of Professional Science Editing for Scientists @ prosciediting.com