Two well established interactions between the SC domain and the OC justify our basic assumptions: (i) CLV3 expression in the SCs is induced by WUS, which is expressed in the OC [5].
It established interactions between B class proteins AP3-1 and PI, as well as FUL and SEP4; weaker interactions were detected between AG and SEP4 and SEP3 and SEP4.
It is now well established that interaction between inhibitory receptors and their self-MHC class-I ligands affects NK cell education.
Although the concept of multidisciplinary teams is now well established, the interaction between members of the teams is much less well defined, particularly as to who is responsible for managing patients through the diagnostic pathway.
Second, there is a well established physical interaction between CBP/p300 and p160 coactivators [ 13, 30- 32], and several groups have proposed that CBP and other coregulators, e.g., p160s, exist in the cytoplasm in preformed complexes [ 33, 34].
It is also well established that interactions between the extra-cellular matrix and cells [ 13] as well as cell-cell interactions play a major role in myogenesis [ 13].
Finally, it is already well established that interactions between the tumour and its microenvironment play an important role in influencing the behaviour of tumour cells.
It is now well established that interactions between smoking and the SE increase the risk of developing RA [ 37] through effects mediated in the early pre-clinical stage of RA [ 38, 39].
As it is well established that the interaction between proline-rich gluten derived peptides and the human HLA-DQ2 molecules induces immune responses that lead to disease development, we have now designed a series of gluten peptides in which proline residues were replaced by azidoprolines.
Overall, it is in fact well established that the interactions between 'iron' sensu lato and partly reduced forms of oxygen can lead to the production of the very damaging hydroxyl radical (e.g. [ 43, 130- 139]), and that this radical in particular probably underpins or mediates many higher-level manifestations of tissue damage, disease, organ failure and ultimately death[ 36, 137, 140- 143].
