Although the functionality of MT1 in many solid tissue cancers is well established, information on its role in ovarian cancer is limited.
While the role of different pro-survival Bcl-2 proteins appears well established, information on the relevance of their antagonists, the proteins of the BH3-only subgroup of the Bcl-2 family, including Bim, Bid, Puma and Bmf, is currently lacking.
In this work we present a model to predict these unknown interactions from a textual collection using the vector space model (VSM), a well known and established information retrieval model.
For the design of large and highly complex facilities – like, the international project ITER (http://www.iter.org/) – reliable basic data with well established covariance information (uncertainties, correlations) are indispensable.
We had chosen to utilize an MI-based approach because MI is well established in Information Theory.
The dynamics of HPV infection during pregnancy is not well established and information remains scarce and controversial.
Although it is well established that information about the structure and position of LINE elements in genes is important for functional studies of genetic diseases, such data are limited and are not included in any database that allows large amounts of scattered information to be searched easily.
Petri net (PN) models are well established in information theory (see Murata, 1989, for a review) and have been extensively applied to biochemical processes, like metabolic pathways (e.g. Küffner et al., 2000) and gene regulatory networks (reviewed in Chaouiya, 2007).
Interpol for its part, says it is too early to have firmly established information on any well-worn routes for the smuggling of artefacts, and is also still compiling information on those suspected of smuggling.
Graph theory is a well established mainstay of information technology and is concerned with highly efficient network flow.
For example, it is well established that as information from different modalities becomes more temporally and spatially congruent, it is more likely to be perceived as coming from a common source47, 48.
