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Although a reduced heart rate variability in continuous ECG recordings is a well established index of diabetic neuropathy, only one study assessed heart rate variability from ambulatory BP recordings in diabetic subjects.
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And there are well established clinical index systems assessing reproducible plaque scores.
Recent reports from our laboratory [ 11] have shown that the presence of TPO antibodies is associated with a significant improvement in both disease-free and overall outcome in breast cancer patients, and that the magnitude of this prognostic effect was of a similar order of magnitude to well established prognostic indices for breast cancer such as axillary nodal status or tumour size.
The established index system is shown in Table 1.
The EQ-5D is a well established health-utility index measure and was originally designed to complement other forms of quality of life measures.
It has been well established that the plasticity index and also the size, shape, and arrangement of soil particles will affect the treatment process of natural soils with additives.
Finally, the utility of ICU acuity illness scores in the assessment of outcome beyond hospital discharge has not been well established, whereas, the Charlson index is an accepted method of risk adjustment in longer term outcome studies in non-ICU patients.
However, none of these indices are as well established in healthcare as the h-index nor are they calculated automatically, as h-index is, by databases such as Scopus or the Web of Science.
The Charlson comorbidity index, a well established methodology to quantify co-morbid disease burden, was calculated for each patient [ 5].
For beta-lactams, the time for which free drug concentrations remains above minimum inhibitory concentration (MIC) as a function of the dosing interval (fT > MIC) is well established to be the pharmacodynamic index predictive of successful response [ 10].
The Charlson index is a well established tool for summarising comorbidity; however there are problems with its use.
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CEO of Professional Science Editing for Scientists @ prosciediting.com