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While the expression of angiotensin converting enzyme (ACE), a key enzyme in the synthesis of angiotensin II (Ang II), is well established, the expression of angiotensin converting enzyme-2 (ACE-2), an enzyme responsible for angiotensin 1 7 generation, is largely unknown.
It is well established that expression traits are heritable (Skelly et al. 2009).
However, it is also well established that expression of Rb can promote cell survival through repression of E2F-driven apoptosis.
To evaluate how the fully optimised custom array setup compares with other technologies, several analyses were performed in parallel on our mouse and human MAS macroarrays and on other well established gene expression platforms.
It is well established that expression of ECM components changes as basement membranes mature and likely involves the initial binding of laminin to dystroglycan with subsequent polymerization of further laminin chains and the cross-linking of the laminin superstructure with other ECM components [ 44].
However, it is now well established that gene expression is a highly polygenic trait in Drosophila melanogaster, with many eQTLs contributing to expression variability both in cis and in trans (Brem et al. 2002, 2005; West et al. 2007), and intralocus genetic complexity influencing a quantitative trait has long been known, as in the Adh example (King et al. 2012).
It is well established that hsp expression can change with diapause [3], [45].
It is well established that altered expression of cell-bound JAM-A under inflammatory conditions may facilitate leukocyte extravasation [10], [11], [12], [16], [17].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com