There is not a well established quantitative exposure response relationship for nitrate exposure via drinking water and the consequential development of methemoglobinemia [ 64].
It's well established that exposure to chemicals in oil, namely benzene, can cause serious health issues, especially respiratory illnesses.
Although it is well established that exposure to nearby nature can help reduce stress in individuals, the shape of the dose response curve is entirely unclear.
It is fairly well established that exposure to environmental tobacco smoke (ETS) is associated with an increased prevalence of respiratory symptoms in young children [ 1- 7].
It is well established that exposure to high levels of Cd may cause kidney damage leading to renal failure (Järup et al. 1998).
The teratogenic effect of alcohol is well established and exposure to alcohol in utero is known to result in a widely variable phenotype.
It is well established that exposure to DDVP and other organophosphorus pesticides results in reactive oxygen stress, injury to mitochondria, lipid peroxidation and other events consistent with elevated ROS levels [ 26].
A well-recognized problem in human health risk assessment has been that while the estimation of risk from single contaminants is fairly well established, human exposures are nearly always to chemical mixtures, or to multiple chemicals in a sequential fashion.
The potential for human exposure to benzene is well established, but quantifying exposure for population-based epidemiologic studies is problematic and requires immense resources.
Since FA-dependent DPX is well established to be exposure dependent in vitro and in other in vivo studies, the absence of exposure-dependent effects at mean concentrations from 0.4 to 2.24 ppm is inexplicable.
