It is well established that conditions experienced during early development contribute critically to phenotypic variation (e.g. [1], [2]) ultimately affecting life-history strategies, reproductive success and survival.
It has been well established that HCWs experienced significant stress during infectious epidemics [ 5- 9].
It is well established that neonates experience pain [ 3, 4].
For example, it is well established that patients having experienced an acute myocardial infarction should receive an aspirin within 24 hours of hospital admission.
While it is well established that women prisoners experience high levels of socioeconomic disadvantage, the policy discussion around short term, remand, and fine default imprisonments has not extended to consider the potential implications of these for children with incarcerated mothers.
In areas of Europe experiencing a well established epidemic of subspecies novo-ulmi that was initially characterized by a uniformity of vc types, vegetative incompatibilities have been reported within six to ten years [ 9].
It is well established that most people will experience low back pain in their lifetime [ 8], that pain is typically recurrent [ 9] and that episodes are usually of sudden onset [ 10].
It is well established that uncontrollable adverse experiences lead to increased distress, but the role of client control during psychological interventions such as exposure is less clear.
It is now well established that prior test experience can alter behavioural baselines and attenuate/abolish the anxiolytic efficacy of benzodiazepines in the elevated plus-maze paradigm.
Like S. cerevisiae, H. polymorpha is characterized by simple cultivation mode in inexpensive growth media, well established genetic tools and experience on industrial cultivation and scaling-up.
First, although the efficacy of immunomodulatory therapy appeared to be lower than for FTY720 in TRANSFORMS and parenteral administration is associated with poorer compliance than for oral preparations, the safety profiles of IFN-β and glatiramer acetate are well established by lengthy postmarketing experience.
