Further, minimizing protein synthesis may also control proliferation as cell cycle arrest is a well established consequence of the general translational arrest, implied from day 15 onwards.
Fragmentation and dispersion of the Golgi apparatus is a well established consequence of inhibition of the dynein/dynactin microtubule motor complex [ 53- 55].
TNFR1-TNF-α-mediated signaling is complex; a well established consequence is the activation of the canonical pathway of NF-κB leading ultimately to IκB degradation and the activation of the NF-κB p50/p65 heterodimer.
Russia and the United States should propose a formal resolution by the United Nations Security Council — of which both are members — to condemn the use of chemical weapons in Syria, support this plan and put its full authority behind carrying it out, as well as establish consequences if Syria reneged.
Loss of 14-3-3 14-3-3 14-3-3ll estabinding, but the consequences of dephosphorylatisn are only nowelling uncovestablished
Increased expression of VEGFR-1 by HIF-1α has been well established, but the consequence of activation of this signalling pathway and its role in stimulating VEGFR-2 expression is not as well characterized [31], [32].
Because the benefits of exercise on health are well established, whereas the net consequences of physical activity in polluted environments remain unclear, recommendations on this topic must carefully weigh the benefits and risks of outdoor physical activity.
Upregulation of p16INK4a and downregulation of pRb are well established and frequent cellular consequences of HPV transformation, and were added here for a stringent definition of HPV-driven tumours.
It is now well established that, as a consequence of sperm competition, males displaying promiscuous sexual behaviour need to invest more energy in the reproductive organs than do monogamous males [ 47].
Higher levels of hepatic apoptosis in CR had been previously reported, although the mechanism responsible for this effect, as well as the consequences, are not well established [ 22].
The tradition of deliberate partisan misunderstanding is now so well established that, partly as a consequence, the really difficult decisions end up in the courts, partly because these are one of the last places, along with the universities, where careful public thought can be applied to public policy.
