This population reached the highest degree of adaptation at the stationary state (see Table 1) and resembles specialist organisms that perform optimally under a narrow range of very well established conditions, but have difficulties to adapt when these conditions are modified [51].
The role of inherited and acquired thrombophilias, well established conditions predisposing to thrombosis, seems to be rather weak for pregnant women after ART, as only one of them showed a common cause of thrombophilia (PTm).
A well-characterized and biochemically established condition is the pH threshold for dimer dissociation.
Nonetheless, the association between lymphocytosis, auto-immune disease and the modulation of neuronal function is well established in conditions such as IBD, neuropathic pain syndromes and many other neurological conditions [ 42- 45].
It is well established that conditions experienced during early development contribute critically to phenotypic variation (e.g. [1], [2]) ultimately affecting life-history strategies, reproductive success and survival.
As we could not make absolute measures of confidence we decided to compare confidence levels against other well established chronic conditions managed in primary care.
A relationship between impaired bone health and back pain is well established in conditions such as osteoporosis, osteoarthritis and inflammatory arthritis.
The combinations hypertension-diabetes, hypertension-lipid disorder, hypertension-overweight, hypertension-ischemic heart disease, hypertension-heart failure and diabetes-overweight are quite well covered within disease-specific guidelines because these combinations concern well established comorbid conditions based on causal associations [ 16, 17].
This approach ignores heterogeneity within the ASD sample, yet it is well established that the condition is a "spectrum" and that presentation varies enormously within the spectrum.
We have demonstrated that patients with pulmonary fibrosis and advanced centrilobular emphysema, a well established chronic inflammatory condition of the lung, have a better prognosis than patients with pulmonary fibrosis without emphysema or those with fibrosis and trivial amounts of emphysema.
It is well established that soil conditions play an important role in driving denitrification.
