It is well established that changes in the phenotype depend much more on changes in gene expression than on changes in protein-coding genes, and that cis-regulatory sequences and chromatin structure are two major factors influencing gene expression.
Previously, it has been well established that changes in unique ECM properties of tumor cells and their microenvironment may lead to changes in cell behavior during cancer progression [ 12, 93].
It is well established that changes in cognitive factors such as knowledge, beliefs, and attitudes do not necessarily translate into behavior change [ 49, 50].
It is well established that changes in gene expression can vary significantly following exposure to subclinical, clinical, and super-clinical radiation doses.
It is well established that changes in actin organization and the levels of its binding proteins are essential to the cancer cell phenotype (reviewed in [ 27, 28]).
It is well established that changes in muscle mass and strength tend to be dissociated in elderly persons, the decline of muscle strength being three times faster than the decrease of muscle mass (Peterson et al., 2012).
It is well established that changes in the important positions of a network could trigger a more severe impact on the pathway than that in the marginal or relatively isolated positions [ 22].
For example, although it is well established that changes in SO2 emissions can influence nitrate particle concentrations by affecting available ammonia levels [ 24], CALPUFF does not capture this phenomenon for an analysis of a small subset of sources.
An immediate consequence of the exposure to glucose is a rise in the concentration of internal cAMP [ 1, 2], and it is well established that changes in cAMP levels affect the transcription rate of a large number of genes in S. cerevisiae [ 3- 5].
Safety checks for arterial and CVC lines were well established and changed little.
