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The well established association between the CARDs of apoptosis protease activating factor-1 (APAF-1) and caspase-9 was considered as a paradigm for a CARD-CARD-mediated binding and served as prove of principle.
In fact, there is a well established association between an ineffective MMR system and mutations in the target genes that we have studied, which presumably play a relevant role in colorectal carcinogenesis through the MSI pathway [ 9, 33].
The endothelium is critically involved in the pathology of multiple diseases, in which there exist a well established association between endothelial dysfunction and/or damage and poor outcome [ 8, 9, 20- 24].
There is a well established association between atypical ductal epithelium identified by histological biopsy [ 3], nipple aspiration (NA) [ 4] or fine needle aspiration (FNA) [ 5] and an increased risk of future breast cancer.
Given the well established association between these problems and risky drinking, it is particularly important to gain a better understanding of the factors contributing to alcohol use in rural regions.
There is a well established association between NSAIDs and GORD, which our study suggests may be higher in magnitude with tibolone use although our findings are not statistically significant.
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To specify the construct validity of the FEE, the well established associations between perceived parental rearing behavior and life satisfaction as well as interpersonal problems were tried to be replicated using the FEE.
The impact of oral disease is not confined to the mouth, with well established associations between chronic oral infections and heart [ 8] and lung diseases, diabetes [ 9], stroke [ 10] and pre-term low birth weight [ 11, 12].
Whereas the association between ACPA-positive RA and SE-containing HLA class II molecules is well established, the association between HLA-DR protective versus non-predisposing alleles and ACPA-negative RA is controversial.
Although not well established, an association between epoetin alfa, a human recombinant erythropoietin, and anterior uveitis has been reported previously in the literature, with 13 patients across three medical centers developing anterior uveitis after receiving epoetin alfa during hemodialysis [2].
While increased risk of ischemic stroke among persons with migraine, and particularly with migraine with aura, has been well established, the association between migraine with aura and overall cardiovascular disease including coronary heart disease has been long debated [86 94].
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