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T. vaginalis, N. gonorrhoeae and C. trachomatis are well established agents of STIs.
To introduce these protocols, new agents or new regimens with the well established agents may be required.
Trichomonas vaginalis, Neisseria gonorrhea and Chlamydia trachomatis are well established agents of STIs leading to vaginal discharge in women.
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More importantly, the C. elegans screen was able to detect most of the well established antifungal agents (Table 1 and Table 2).
It is well established that agents that are capable of inducing apoptosis as mode of cell death are good anticancer candidates [ 37].
Dyslipidemia is a well established proinflammatory agent in large arterial vessel disease[21] and could be of importance in the pathogenesis of microvascular complications of diabetes[22].
DFO is a well established hypoxymimetic agent [ 26].
Preconditioning is well established, and volatile agents are now recommended as the agent of choice by the American Heart Association for high-risk patients [ 4].
It is well established that pharmacological agents, including the combination of apamin and charybdotoxin [34], inhibit EDHF by antagonizing calcium activated potassium channels on vascular endothelial cells in ex vivo experiments [34], [35].
The therapeutic efficacy was compared with B20-4.1.1 (B20), the humand and mouse-VEGF-binding monoclonal antibody (Liang et al, 2006; Singh et al, 2010), and the mTOR pathway inhibitor rapamycin (RAPA) (Guba et al, 2002), two well established anti-angiogenic agents.
The experiments, each were carried out each in triplicate and the results are tabulated in Table 1 and compared with the standard drug Rutin (Fig. 7), a bioflavanol which is a well established promising anticancer agent and its mechanism may be due to the induction of apoptosis [ 21].
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