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We defined an SNP as displaying clear lineage-specific differentiation when the difference in mbuna and non-mbuna allele frequencies was equal or greater than 0.75, and hence calculated the proportion of high-MAF SNPs that were well differentiated between lineages.
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We found significant differences in overall survival between patients with different histologic tumor grades (divided in accordance with three-tier grading scheme: G1/G2/G3) (Fig. 2c) as well as between cases with well differentiated (differentiation grade 1) and poorly differentiated tumors (differentiation grades II III) (Fig. 2d).
As far as it concerns the grade of cancer it seemed that there was no significant differences neither between macroscopically normal samples of poor, moderately and well differentiated specimens nor between cancerous ones.
Histologically, 11% of the samples were well differentiated, 33% moderately well differentiated and 56% poorly differentiated.
Quantitative analysis and hierarchical clustering of the expression patterns revealed two well differentiated groups of transcripts behaving differentially between the two ecotypes.
There was a clear difference in Eag1 expression levels between well differentiated liposarcoma (21.1%) and pleomorphic/round cell liposarcoma.
[ 18] is facilitated by a comparatively recent divergence [ 19], roach and bream represent well differentiated genera, thus hybridisation between these species further highlights a readiness to hybridise amongst leuciscinae.
They proposed a clinicopathological entity of poorly differentiated carcinoma, and hypothesised that this type of carcinoma falls between well differentiated carcinoma and undifferentiated carcinoma, although it is still an open question whether showing such growth patterns is truly due to the dedifferentiation of carcinoma.
Histological features (Grade of differentiation); well: well differentiated; mod: moderately well differentiated; poor: poorly differentiated.
Differential diagnosis between keratoacanthomas and well differentiated squamous cell carcinomas based on clinical and histomorphological data is problematic.
Cases diagnosed as atypical were subject to differential diagnosis between hyperplasia with atypia and well differentiated adenocarcinoma.
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